G-protein coupled receptor structure
نویسندگان
چکیده
منابع مشابه
G-protein Coupled Receptor Dimerization
A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...
متن کاملG protein coupled receptor structure and activation.
G protein coupled receptors (GPCRs) are remarkably versatile signaling molecules. The members of this large family of membrane proteins are activated by a spectrum of structurally diverse ligands, and have been shown to modulate the activity of different signaling pathways in a ligand specific manner. In this manuscript I will review what is known about the structure and mechanism of activation...
متن کاملReceptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure
The organization of Rhodopsin-family G protein-coupled receptors (GPCRs) at the cell surface is controversial. Support both for and against the existence of dimers has been obtained in studies of mostly individual receptors. Here, we use a large-scale comparative study to examine the stoichiometric signatures of 60 receptors expressed by a single human cell line. Using bioluminescence resonance...
متن کاملG-protein-coupled receptor structure: what can we learn?
The first, long-awaited, structures of non-visual G-protein-coupled receptors have provided important insights into the process of ligand binding and receptor activation. Here I explore the technological advances that enabled the resolution of the crystal structures of the β(1)- and β(2)-adrenergic receptors, and review what we have learnt and what is still to be discovered.
متن کاملHanson Coupled Receptor − Crystal Structure of a Lipid G Protein
clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): March 3, 2013 www.sciencemag.org (this information is current as of The following resources related to this article are availa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2007
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2006.10.002